Brain diffusion‐weighted imaging in Friedreich's ataxia
Identifieur interne : 000382 ( Main/Exploration ); précédent : 000381; suivant : 000383Brain diffusion‐weighted imaging in Friedreich's ataxia
Auteurs : Giovanni Rizzo [Italie] ; Caterina Tonon [Italie] ; Maria Lucia Valentino [Italie] ; David Manners [Italie] ; Filippo Fortuna [Italie] ; Cinzia Gellera [Italie] ; Antonella Pini [Italie] ; Alessandro Ghezzo [Italie] ; Agostino Baruzzi [Italie] ; Claudia Testa [Italie] ; Emil Malucelli [Italie] ; Bruno Barbiroli [Italie] ; Valerio Carelli [Italie] ; Raffaele Lodi [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 2011-03.
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Abstract
Background:: Friedreich ataxia (FRDA) is the commonest form of autosomal recessive ataxia. This study aimed to define the extent of the brain damage in FRDA patients and to identify in vivo markers of neurodegeneration, using diffusion‐weighted imaging (DWI). Methods:: We studied 27 FRDA patients and 21 healthy volunteers using a 1.5 T scanner. Axial DW images were obtained and mean diffusivity (MD) maps were generated. Region of interests (ROIs) included medulla, pons, inferior, middle and superior cerebellar peduncles (ICP, SCP, MCP), dentate nucleus, cerebellar white matter, thalamus, caudate, putamen, pallidus, pyramidal tracts at level of posterior limb of internal capsule (PLIC), optic radiations (OR), and corpus callosum. Histograms of MD were generated for all pixels in the whole cerebral hemispheres and infratentorial compartment. Disease severity was assessed by the International Cooperative Ataxia Rating Scale (ICARS). Results:: FRDA patients had significantly higher MD values than controls in medulla (P < 0.001), ICP (P < 0.001), MCP (P < 0.01), SCP (P < 0.001), OR (P < 0.001), and at the level of the infratentorial structures such as brainstem (P < 0.01), cerebellar hemispheres (P < 0.01), and especially in the cerebellar vermis (P < 0.001). MD values were strongly correlated with disease duration and ICARS score. Discussion:: Our results showed that DWI is a suitable non‐invasive technique to quantify the extent of neurodegeneration in FRDA, that appears more extended than previously reported, showing a microstructural involvement of structures such as OR and MCP. © 2011 Movement Disorder Society
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DOI: 10.1002/mds.23518
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uniqKey="Valentino M" first="Maria Lucia" last="Valentino">Maria Lucia Valentino</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, University of Bologna, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Manners, David" sort="Manners, David" uniqKey="Manners D" first="David" last="Manners">David Manners</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Fortuna, Filippo" sort="Fortuna, Filippo" uniqKey="Fortuna F" first="Filippo" last="Fortuna">Filippo Fortuna</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, University of Bologna, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Gellera, Cinzia" sort="Gellera, Cinzia" uniqKey="Gellera C" first="Cinzia" last="Gellera">Cinzia Gellera</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>U.O. Biochemistry and Genetics, Fondazione IRCCS‐Istituto Neurologico Nazionale “Carlo Besta”, Milano</wicri:regionArea><wicri:noRegion>Milano</wicri:noRegion></affiliation></author><author><name sortKey="Pini, Antonella" sort="Pini, Antonella" uniqKey="Pini A" first="Antonella" last="Pini">Antonella Pini</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Neuropsichiatric Unit, Ospedale Maggiore, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Ghezzo, Alessandro" sort="Ghezzo, Alessandro" uniqKey="Ghezzo A" first="Alessandro" last="Ghezzo">Alessandro Ghezzo</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Neuropsichiatric Unit, Ospedale Maggiore, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Baruzzi, Agostino" sort="Baruzzi, Agostino" uniqKey="Baruzzi A" first="Agostino" last="Baruzzi">Agostino Baruzzi</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, University of Bologna, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Testa, Claudia" sort="Testa, Claudia" uniqKey="Testa C" first="Claudia" last="Testa">Claudia Testa</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Malucelli, Emil" sort="Malucelli, Emil" uniqKey="Malucelli E" first="Emil" last="Malucelli">Emil Malucelli</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Barbiroli, Bruno" sort="Barbiroli, Bruno" uniqKey="Barbiroli B" first="Bruno" last="Barbiroli">Bruno Barbiroli</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Carelli, Valerio" sort="Carelli, Valerio" uniqKey="Carelli V" first="Valerio" last="Carelli">Valerio Carelli</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Neurological Sciences, University of Bologna, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Lodi, Raffaele" sort="Lodi, Raffaele" uniqKey="Lodi R" first="Raffaele" last="Lodi">Raffaele Lodi</name><affiliation wicri:level="1"><country xml:lang="fr">Italie</country><wicri:regionArea>MR Spectroscopy Unit, Department of Internal Medicine, Aging and Nephrology, University of Bologna, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Movement Disorders</title><title level="j" type="abbrev">Mov. Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2011-03">2011-03</date><biblScope unit="volume">26</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="705">705</biblScope><biblScope unit="page" to="712">712</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">74A749AB62758B4B7AE369D7165AFEBB9A1B7E12</idno><idno type="DOI">10.1002/mds.23518</idno><idno type="ArticleID">MDS23518</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Friedreich's ataxia</term><term>MRI</term><term>diffusion‐weighted imaging</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background:: Friedreich ataxia (FRDA) is the commonest form of autosomal recessive ataxia. This study aimed to define the extent of the brain damage in FRDA patients and to identify in vivo markers of neurodegeneration, using diffusion‐weighted imaging (DWI). Methods:: We studied 27 FRDA patients and 21 healthy volunteers using a 1.5 T scanner. Axial DW images were obtained and mean diffusivity (MD) maps were generated. Region of interests (ROIs) included medulla, pons, inferior, middle and superior cerebellar peduncles (ICP, SCP, MCP), dentate nucleus, cerebellar white matter, thalamus, caudate, putamen, pallidus, pyramidal tracts at level of posterior limb of internal capsule (PLIC), optic radiations (OR), and corpus callosum. Histograms of MD were generated for all pixels in the whole cerebral hemispheres and infratentorial compartment. Disease severity was assessed by the International Cooperative Ataxia Rating Scale (ICARS). Results:: FRDA patients had significantly higher MD values than controls in medulla (P < 0.001), ICP (P < 0.001), MCP (P < 0.01), SCP (P < 0.001), OR (P < 0.001), and at the level of the infratentorial structures such as brainstem (P < 0.01), cerebellar hemispheres (P < 0.01), and especially in the cerebellar vermis (P < 0.001). MD values were strongly correlated with disease duration and ICARS score. Discussion:: Our results showed that DWI is a suitable non‐invasive technique to quantify the extent of neurodegeneration in FRDA, that appears more extended than previously reported, showing a microstructural involvement of structures such as OR and MCP. © 2011 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><country name="Italie"><noRegion><name sortKey="Rizzo, Giovanni" sort="Rizzo, Giovanni" uniqKey="Rizzo G" first="Giovanni" last="Rizzo">Giovanni Rizzo</name></noRegion><name sortKey="Barbiroli, Bruno" sort="Barbiroli, Bruno" uniqKey="Barbiroli B" first="Bruno" last="Barbiroli">Bruno Barbiroli</name><name sortKey="Baruzzi, Agostino" sort="Baruzzi, Agostino" uniqKey="Baruzzi A" first="Agostino" last="Baruzzi">Agostino Baruzzi</name><name sortKey="Carelli, Valerio" sort="Carelli, Valerio" uniqKey="Carelli V" first="Valerio" last="Carelli">Valerio Carelli</name><name sortKey="Fortuna, Filippo" sort="Fortuna, Filippo" uniqKey="Fortuna F" first="Filippo" last="Fortuna">Filippo Fortuna</name><name sortKey="Fortuna, Filippo" sort="Fortuna, Filippo" uniqKey="Fortuna F" first="Filippo" last="Fortuna">Filippo Fortuna</name><name sortKey="Gellera, Cinzia" sort="Gellera, Cinzia" uniqKey="Gellera C" first="Cinzia" last="Gellera">Cinzia Gellera</name><name sortKey="Ghezzo, Alessandro" sort="Ghezzo, Alessandro" uniqKey="Ghezzo A" first="Alessandro" last="Ghezzo">Alessandro Ghezzo</name><name sortKey="Lodi, Raffaele" sort="Lodi, Raffaele" uniqKey="Lodi R" first="Raffaele" last="Lodi">Raffaele Lodi</name><name sortKey="Malucelli, Emil" sort="Malucelli, Emil" uniqKey="Malucelli E" first="Emil" last="Malucelli">Emil Malucelli</name><name sortKey="Manners, David" sort="Manners, David" uniqKey="Manners D" first="David" last="Manners">David Manners</name><name sortKey="Pini, Antonella" sort="Pini, Antonella" uniqKey="Pini A" first="Antonella" last="Pini">Antonella Pini</name><name sortKey="Rizzo, Giovanni" sort="Rizzo, Giovanni" uniqKey="Rizzo G" first="Giovanni" last="Rizzo">Giovanni Rizzo</name><name sortKey="Testa, Claudia" sort="Testa, Claudia" uniqKey="Testa C" first="Claudia" last="Testa">Claudia Testa</name><name sortKey="Tonon, Caterina" sort="Tonon, Caterina" uniqKey="Tonon C" first="Caterina" last="Tonon">Caterina Tonon</name><name sortKey="Valentino, Maria Lucia" sort="Valentino, Maria Lucia" uniqKey="Valentino M" first="Maria Lucia" last="Valentino">Maria Lucia Valentino</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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